Histopathological changes in the upper respiratory tract of F344 rats following infection with a rat-adapted influenza virus.
AuthorsIbanes JD, Morgan KT, Burleson GR
JournalVet Pathol
PubMed ID8817839
'The present study determined the morphogenesis of upper respiratory tract disease in rats following infection with a rat-adapted influenza virus. Sixty-eight 60-day-old, male F344 rats were infected by intranasal inoculation and necropsied at days 1, 2, 4, 7, 14, and 28 post-inoculation (PI). Responses to infection were studied by routine ... More
Fas ligand is positioned in mouse uterus and placenta to prevent trafficking of activated leukocytes between the mother and the conceptus.
AuthorsHunt JS, Vassmer D, Ferguson TA, Miller L
JournalJ Immunol
PubMed ID9126971
'Despite intimate juxtaposition of maternal and fetal tissues during mammalian pregnancy, reciprocal migration of cells is limited. To evaluate the postulate that cell traffic is restricted by expression of Fas ligand (FasL) in the uterus and placenta, FasL mRNA was identified by using reverse transcription-PCR, and FasL protein was identified ... More
CD8Tc1 and Tc2 cells secrete distinct cytokine patterns in vitro and in vivo but induce similar inflammatory reactions.
AuthorsLi L, Sad S, Kägi D, Mosmann TR
JournalJ Immunol
PubMed ID9126975
Naive CD8 T cells, similar to CD4 T cells, can differentiate into at least two subsets of cytolytic effector cells with distinct cytokine patterns: T cytotoxic-1 (Tc1) cells secrete a Th1-like cytokine pattern, including IL-2 and IFN-gamma; and Tc2 cells produce Th2 cytokines, including IL-4, IL-5, and IL-10. As CD4 ... More
Bromodeoxyuridine immunohistochemistry of epon-embedded undecalcified bone in a canine fracture healing model.
AuthorsXiang Z, Markel MD
JournalJ Histochem Cytochem
PubMed ID7769234
We evaluated bromodeoxyuridine (BrdU) immunohistochemistry of paraffin-, methyl methacrylate (MMA)-, and epon-araldite (epon)-embedded canine bone specimens to establish an optimal technique for studying cell kinetics of fracture healing in a canine tibial gap model. Dogs were sacrificed 4 months after tibial ostectomy and 1 hr after i.v. injection of BrdU ... More