Carcinomas in situ of the breast with indeterminate features: role of E-cadherin staining in categorization.
AuthorsJacobs TW, Pliss N, Kouria G, Schnitt SJ
JournalAm J Surg Pathol
PubMed ID11176072
'Most breast carcinomas in situ (CIS) are easily categorized as ductal (DCIS) or lobular (LCIS). However, some CIS have indeterminate histologic features (CIS-IF). Prior studies have shown that E-cadherin protein expression is lost in lobular but not ductal carcinomas. Therefore, evaluation of examples of CIS-IF for E-cadherin expression by immunohistochemistry ... More
The chemopreventive capacity of quercetin to induce programmed cell death in hepatocarcinogenesis.
In this study of chemoprevention in the rat modified resistant hepatocyte model, preneoplastic cells were diminished by >60% with quercetin pretreatment compared with those rats treated with N-Diethylnitrosamine (DEN) to induce liver cancer. This decrease occurred associated with an abolished DEN-induced lipid peroxidation as well as activation of caspase 9 ... More