Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils.
AuthorsEl Khoury J, Hickman SE, Thomas CA, Cao L, Silverstein SC, Loike JD
JournalNature
PubMed ID8751442
'A pathological hallmark of Alzheimer''s disease is the senile plaque, containing beta-amyloid fibrils, microglia and astrocytes. Beta-amyloid fibrils exert a cytotoxic effect on neurons, and stimulate microglia to produce neurotoxins, such as reactive oxygen species. Mononuclear phagocytes, including microglia, express scavenger receptors that mediate endocytosis of oxidized low-density lipoproteins, and ... More