Patients with Alzheimer disease have lower levels of serum anti-amyloid peptide antibodies than healthy elderly individuals.
AuthorsWeksler ME, Relkin N, Turkenich R, LaRusse S, Zhou L, Szabo P
JournalExp Gerontol
PubMed ID12086704
'Active immunization with the human amyloid peptide (Abeta42) or passive immunization with anti-Abeta42 antibodies protects mice that express a mutant human amyloid precursor protein (APP) transgene from cerebral amyloid deposits. If anti-Abeta42 antibodies protect APP-transgenic mice, a model of Alzheimer''s disease (AD), a high titer of anti-Abeta42 antibodies may protect ... More