Nek11, a new member of the NIMA family of kinases, involved in DNA replication and genotoxic stress responses.
AuthorsNoguchi K, Fukazawa H, Murakami Y, Uehara Y
JournalJ Biol Chem
PubMed ID12154088
DNA replication and genotoxic stresses activate various checkpoint-associated protein kinases, and checkpoint dysfunction often leads to cell lethality. Here, we have identified new members of the mammalian NIMA family of kinases, termed Nek11L and Nek11S (NIMA-related kinase 11 Long and Short isoform) as novel DNA replication/damage stresses-responsive kinases. Molecular cloning ... More