The human poliovirus receptor related 2 protein is a new hematopoietic/endothelial homophilic adhesion molecule.
AuthorsLopez M, Aoubala M, Jordier F, Isnardon D, Gomez S, Dubreuil P
JournalBlood
PubMed ID9845526
'We have recently described Poliovirus Receptor Related 2 (PRR2), a new cell surface molecule homologous to the poliovirus receptor (PVR/CD155). Both molecules are transmembrane glycoproteins belonging to the Ig superfamily (IgSF). They contain 3 Ig domains of V, C2, and C2 types in their extracellular regions that share 51% aa ... More
Cell-to-cell spread of wild-type herpes simplex virus type 1, but not of syncytial strains, is mediated by the immunoglobulin-like receptors that mediate virion entry, nectin1 (PRR1/HveC/HIgR) and nectin2 (PRR2/HveB).
AuthorsCocchi F, Menotti L, Dubreuil P, Lopez M, Campadelli-Fiume G
JournalJ Virol
PubMed ID10729168
'The immunoglobulin-like receptors that mediate entry of herpes simplex virus type 1 (HSV-1) into human cells were found to mediate the direct cell-to-cell spread of wild-type virus. The receptors here designated Nectin1alpha and -delta and Nectin2alpha were originally designated HIgR, PRR1/HveC, and PRR2alpha/HveB, respectively. We report the following. (i) Wild-type ... More
Identification and characterization of murine DNAM-1 (CD226) and its poliovirus receptor family ligands.
AuthorsTahara-Hanaoka S, Miyamoto A, Hara A, Honda S, Shibuya K, Shibuya A
JournalBiochem Biophys Res Commun
PubMed ID15752754
'The leukocyte adhesion molecule DNAM-1 (CD226) is a member of the immunoglobulin superfamily and constitutively expressed on the majority of CD4+ and CD8+ T lymphocytes, natural killer (NK) cells, monocytes/macrophages, and a subset of B lymphocytes. The poliovirus receptor (PVR; CD155) and its family member nectin 2 (CD112) have recently ... More
Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process.
AuthorsBachelet I, Munitz A, Mankutad D, Levi-Schaffer F
JournalJ Biol Chem
PubMed ID16831868
Mast cells have critical effector functions in various immune reactions. In allergic inflammation, mast cells interact with tissue-infiltrating eosinophils, forming a regulatory unit in the late and chronic phases of the allergic process. However, the pathways and molecules within this unit are still largely undefined. Here, we show that human ... More
Restoration of E-cadherin-based cell-cell adhesion by overexpression of nectin in HSC-39 cells, a human signet ring cell gastric cancer cell line.
AuthorsPeng YF, Mandai K, Nakanishi H, Ikeda W, Asada M, Momose Y, Shibamoto S, Yanagihara K, Shiozaki H, Monden M, Takeichi M, Takai Y
JournalOncogene
PubMed ID12037667
Nectin is an immunoglobulin-like adhesion molecule that comprises a family consisting of four members, nectin-1, -2, -3, and -4. Nectin is associated with the actin cytoskeleton through afadin, a nectin- and actin filament-binding protein. The nectin-afadin and cadherin-catenin systems are associated with each other and cooperatively form cell-cell adherens junctions ... More