Inducible nitric-oxide synthase attenuates vasopressin-dependent Ca2+ signaling in rat hepatocytes.
Authors Patel Sandip; Gaspers Lawrence D; Boucherie Sylviane; Memin Elisabeth; Stellato Kerri Anne; Guillon Gilles; Combettes Laurent; Thomas Andrew P;
JournalJ Biol Chem
PubMed ID12097323
'Increases in both Ca(2+) and nitric oxide levels are vital for a variety of cellular processes; however, the interaction between these two crucial messengers is not fully understood. Here, we demonstrate that expression of inducible nitric-oxide synthase in hepatocytes, in response to inflammatory mediators, dramatically attenuates Ca(2+) signaling by the ... More