Tissue-specific enhancer-promoter interactions regulate high level constitutive expression of matrix metalloproteinase 2 by glomerular mesangial cells.
Authors Harendza S; Pollock A S; Mertens P R; Lovett D H;
JournalJ Biol Chem
PubMed ID7642529
The 72-kDa gelatinase A (MMP-2) is a central mediator of the response of the intrinsic glomerular mesangial cell to inflammatory stimuli and is regulated in a unique, cell-specific manner. We isolated a 6-kilobase pair genomic fragment of the rat MMP-2 gene and sequenced and characterized 1686-base pair of the 5'-flanking ... More
High density lipoprotein binding to scavenger receptor, Class B, type I activates endothelial nitric-oxide synthase in a ceramide-dependent manner.
Authors Li Xiang-An; Titlow William B; Jackson Brian A; Giltiay Nathalia; Nikolova-Karakashian Mariana; Uittenbogaard Annette; Smart Eric J;
JournalJ Biol Chem
PubMed ID11792700
Recently it has been demonstrated that high density lipoprotein (HDL) binding to scavenger receptors, class B, type I (SR-BI) stimulates endothelial nitric-oxide synthase (eNOS) activity. In the present studies we used a Chinese hamster ovary cell system and a human microvascular endothelial cell line to confirm that HDL stimulates eNOS ... More