Resolving cadherin interactions and binding cooperativity at the single-molecule level.
AuthorsZhang Y, Sivasankar S, Nelson WJ, Chu S,
JournalProc Natl Acad Sci U S A
PubMed ID19114658
The cadherin family of Ca(2+)-dependent cell adhesion proteins are critical for the morphogenesis and functional organization of tissues in multicellular organisms, but the molecular interactions between cadherins that are at the core of cell-cell adhesion are a matter of considerable debate. A widely-accepted model is that cadherins adhere in 3 ... More