Expression of MCAM/MUC18 by human melanoma cells leads to increased tumor growth and metastasis.
AuthorsXie S, Luca M, Huang S, Gutman M, Reich R, Johnson JP, Bar-Eli M
JournalCancer Res
PubMed ID9187135
'The cell surface adhesion molecule MCAM (MUC18) is strongly expressed by advanced primary and metastatic melanomas but is weaker and less frequent in nevus cells. Previous studies have shown that MCAM expression correlates with tumor thickness and metastatic potential of human melanoma cells in nude mice. To provide direct evidence ... More
MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily.
AuthorsLehmann JM, Riethmüller G, Johnson JP
JournalProc Natl Acad Sci U S A
PubMed ID2602381
'The MUC18 antigen is an integral membrane glycoprotein of 113 kDa whose expression on primary human melanomas correlates with poor prognosis and the development of metastatic disease. MUC18 is expressed only sporadically in benign melanocytic nevi and thin primary melanomas that have a low probability of metastasizing. However, with increasing ... More
The role of CD146 (Mel-CAM) in biology and pathology.
AuthorsShih IM
JournalJ Pathol
PubMed ID10451481
CD146, also known as Mel-CAM, MUC18, A32 antigen, and S-Endo-1, is a membrane glycoprotein which functions as a Ca(2+)-independent cell adhesion molecule involved in heterophilic cell-cell interactions. Based on homology of the nucleotide sequence, CD146 is classified as a member of the immunoglobulin gene superfamily, since it contains the characteristic ... More
Dual role of melanoma cell adhesion molecule (MCAM)/CD146 in lymphocyte endothelium interaction: MCAM/CD146 promotes rolling via microvilli induction in lymphocyte and is an endothelial adhesion receptor.
AuthorsGuezguez B, Vigneron P, Lamerant N, Kieda C, Jaffredo T, Dunon D
JournalJ Immunol
PubMed ID17982057
The melanoma cell adhesion molecule (MCAM)/CD146 is expressed as two isoforms differing by their cytoplasmic domain (MCAM long (MCAM-l) and MCAM short (MCAM-s)). MCAM being expressed by endothelial cells and activated T cells, we analyzed its involvement in lymphocyte trafficking. The NK cell line NKL1 was transfected by MCAM isoforms ... More