Requirement of p53 targets in chemosensitization of colonic carcinoma to death ligand therapy.
AuthorsWang S, El-Deiry WS,
JournalProc Natl Acad Sci U S A
PubMed ID14645705
'Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) exhibits specific tumoricidal activity and is under development for cancer therapy. Mismatch-repair-deficient colonic tumors evade TRAIL-induced apoptosis through mutational inactivation of Bax, but chemotherapeutics including Camptosar (CPT-11) restore TRAIL sensitivity. However, the signaling pathways in restoring TRAIL sensitivity remain to be elucidated. Here, we ... More
Transepithelial transport of HIV-1 by M cells is receptor-mediated.
'Human colon carcinoma Caco-2 cell monolayers undergo conversion into cells that share morphological and functional features of M cells when allowed to interact with B lymphocytes. A lymphotropic (X4) HIV-1 strain crosses M cell monolayers and infects underlying CD4(+) target cells. Transport requires both lactosyl cerebroside and CXCR4 receptors, which ... More
Global genome repair is required to activate KIN17, a UVC-responsive gene involved in DNA replication.
AuthorsMasson C, Menaa F, Pinon-Lataillade G, Frobert Y, Chevillard S, Radicella JP, Sarasin A, Angulo JF,
JournalProc Natl Acad Sci U S A
PubMed ID12525703
UV light provokes DNA lesions that interfere with replication and transcription. These lesions may compromise cell viability and usually are removed by nucleotide excision repair (NER). In humans, inactivation of NER is associated with three rare autosomal recessive inherited disorders: xeroderma pigmentosum (XP), Cockayne syndrome, and trichothiodystrophy. The NER earliest ... More
Molecular cross-talk between the TRAIL and interferon signaling pathways.
Authors Kumar-Sinha Chandan; Varambally Sooryanarayana; Sreekumar Arun; Chinnaiyan Arul M;
JournalJ Biol Chem
PubMed ID11677236
TRAIL/APO-2L induces apoptosis in a variety of transformed cells and has potential as an anti-cancer therapeutic. The physiologic role of TRAIL is presumably more complex than merely activating caspase-mediated cell death. To shed light into TRAIL-mediated signaling, we used DNA microarrays to profile gene expression mediated by TRAIL in breast ... More
TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO.
Authors Deng Yibin; Lin Yahong; Wu Xiangwei;
JournalGenes Dev
PubMed ID11782443
Recent reports suggest that a cross-talk exists between apoptosis pathways mediated by mitochondria and cell death receptors. In the present study, we report that mitochondrial events are required for apoptosis induced by the cell death ligand TRAIL (TNF-related apoptosis-inducing ligand) in human cancer cells. We show that the Bax null ... More