Endoglin structure and function: Determinants of endoglin phosphorylation by transforming growth factor-beta receptors.
AuthorsKoleva RI, Conley BA, Romero D, Riley KS, Marto JA, Lux A, Vary CP
JournalJ Biol Chem
PubMed ID16785228
'Determination of the functional relationship between the transforming growth factor-beta (TGFbeta) receptor proteins endoglin and ALK1 is essential to the understanding of the human vascular disease, hereditary hemorrhagic telangiectasia. TGFbeta1 caused recruitment of ALK1 into a complex with endoglin in human umbilical vein endothelial cells (HUVECs). Therefore, we examined TGFbeta ... More
Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1.
AuthorsMcAllister KA, Grogg KM, Johnson DW, Gallione CJ, Baldwin MA, Jackson CE, Helmbold EA, Markel DS, McKinnon WC, Murrell J
JournalNat Genet
PubMed ID7894484
Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominant disorder characterized by multisystemic vascular dysplasia and recurrent haemorrhage. Linkage for some families has been established to chromosome 9q33-q34. In the present study, endoglin, a transforming growth factor beta (TGF-beta) binding protein, was analysed as a candidate gene for the disorder based ... More
Endoglin (CD105): a marker of tumor vasculature and potential target for therapy.
AuthorsDallas NA, Samuel S, Xia L, Fan F, Gray MJ, Lim SJ, Ellis LM
JournalClin Cancer Res
PubMed ID18381930
Endoglin (CD105) is an accessory protein of the transforming growth factor-beta receptor system expressed on vascular endothelial cells. Mutation of the endoglin gene is associated with hereditary hemorrhagic telangiectasias, or Osler-Weber-Rendu syndrome, and has been studied extensively in the context of this disease. The expression of endoglin is elevated on ... More
Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells.
AuthorsCheifetz S, Bellón T, Calés C, Vera S, Bernabeu C, Massagué J, Letarte M
JournalJ Biol Chem
PubMed ID1326540
Endoglin, a dimeric membrane glycoprotein expressed at high levels on human vascular endothelial cells, shares regions of sequence identity with betaglycan, a major binding protein for transforming growth factor-beta (TGF-beta) that co-exists with TGF-beta receptors I and II in a variety of cell lines but is low or absent in ... More
Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily.
AuthorsBarbara NP, Wrana JL, Letarte M
JournalJ Biol Chem
PubMed ID9872992
Endoglin (CD105) is a transmembrane glycoprotein that binds transforming growth factor (TGF)-beta1 and -beta3, and coprecipitates with the Ser/Thr kinase signaling receptor complex by affinity labeling of endothelial and leukemic cells. The present study shows that in addition to TGF-beta1 and -beta3, endoglin interacts with activin-A, bone morphogenetic protein (BMP)-7, ... More