Leptin and the regulation of body weight in mammals.
AuthorsFriedman JM, Halaas JL
JournalNature
PubMed ID9796811
'The assimilation, storage and use of energy from nutrients constitute a homeostatic system that is essential for life. In vertebrates, the ability to store sufficient quantities of energy-dense triglyceride in adipose tissue allows survival during the frequent periods of food deprivation encountered during evolution. However, the presence of excess adipose ... More
Leptin regulates bone formation via the sympathetic nervous system.
AuthorsTakeda S, Elefteriou F, Levasseur R, Liu X, Zhao L, Parker KL, Armstrong D, Ducy P, Karsenty G
JournalCell
PubMed ID12419242
'We previously showed that leptin inhibits bone formation by an undefined mechanism. Here, we show that hypothalamic leptin-dependent antiosteogenic and anorexigenic networks differ, and that the peripheral mediators of leptin antiosteogenic function appear to be neuronal. Neuropeptides mediating leptin anorexigenic function do not affect bone formation. Leptin deficiency results in ... More
The role of the leptin in reproduction.
AuthorsCervero A, Domínguez F, Horcajadas JA, Quiñonero A, Pellicer A, Simón C
JournalCurr Opin Obstet Gynecol
PubMed ID16735830
'Since its discovery in 1994, leptin has appeared to be a pleiotrophic hormone, governing energy homeostasis and affecting many tissues in the body. Numerous pieces of evidence have accumulated showing that leptin potentially plays an important role in the control of the reproductive function.' ... More
Human leptin: from an adipocyte hormone to an endocrine mediator.
AuthorsWauters M, Considine RV, Van Gaal LF
JournalEur J Endocrinol
PubMed ID11022169
Leptin is a mainly adipocyte-secreted protein that was discovered 5 years ago. Most of the research following this discovery focused on the role of leptin in body weight regulation, aiming to illuminate the pathophysiology of human obesity. However, more and more data are emerging that leptin is not only important ... More
Differential regulation of metabolic, neuroendocrine, and immune function by leptin in humans.
AuthorsChan JL, Matarese G, Shetty GK, Raciti P, Kelesidis I, Aufiero D, De Rosa V, Perna F, Fontana S, Mantzoros CS
JournalProc Natl Acad Sci U S A
PubMed ID16714386
To elucidate whether the role of leptin in regulating neuroendocrine and immune function during short-term starvation in healthy humans is permissive, i.e., occurs only when circulating leptin levels are below a critical threshold level, we studied seven normal-weight women during a normoleptinemic-fed state and two states of relative hypoleptinemia induced ... More