AuthorsLombet A, Planque N, Bleau AM, Li CL, Perbal B
JournalCell Commun Signal
PubMed ID14606958
The CCN family of genes consists presently of six members in human (CCN1-6) also known as Cyr61 (Cystein rich 61), CTGF (Connective Tissue Growth Factor), NOV (Nephroblastoma Overexpressed gene), WISP-1, 2 and 3 (Wnt-1 Induced Secreted Proteins). Results obtained over the past decade have indicated that CCN proteins are matricellular ... More
CCN3: a key growth regulator in Chronic Myeloid Leukaemia.
AuthorsMcCallum L, Lu W, Price S, Lazar N, Perbal B, Irvine AE
JournalJ Cell Commun Signal
PubMed ID19623482
'Chronic Myeloid Leukaemia (CML) is characterized by expression of the constitutively active Bcr-Abl tyrosine kinase. We have shown previously that the negative growth regulator, CCN3, is down-regulated as a result of Bcr-Abl kinase activity and that CCN3 has a reciprocal relationship of expression with BCR-ABL. We now show that CCN3 ... More
CCN3 and bone marrow cells.
AuthorsKatsube K, Ichikawa S, Katsuki Y, Kihara T, Terai M, Lau LF, Tamamura Y, Takeda S, Umezawa A, Sakamoto K, Yamaguchi A
JournalJ Cell Commun Signal
PubMed ID19626464
'CCN3 expression was observed in a broad variety of tissues from the early stage of development. However, a kind of loss of function in mice (CCN3 del VWC domain -/-) demonstrated mild abnormality, which indicates that CCN3 may not be critical for the normal embryogenesis as a single gene. The ... More
CCN3--a key regulator of the hematopoietic compartment.
AuthorsMcCallum L, Irvine AE
JournalBlood Rev
PubMed ID18752874
CCN3, a founding member of the CCN family of growth regulators, was linked with hematology in 2003(1) when it was detected in human serum. CCN3 is expressed and secreted by hematopoietic progenitor cells in normal bone marrow. CCN3 acts through the core stem cell signalling pathways including Notch and Bone ... More