Human Cytomegalovirus Induces Drug Resistance and Alteration of Programmed Cell Death by Accumulation of Delta N-p73alpha.
Authors Allart Sophie; Martin Helene; Detraves Claire; Terrasson Jerome; Caput Daniel; Davrinche Christian;
JournalJ Biol Chem
PubMed ID12034725
'Intrauterine transmission of human cytomegalovirus (HCMV) to the fetus following primary infection in early and late pregnancy usually results in severe neurological handicaps and sensorineural hearing loss with typical migrational anomalies, optic atrophy, disturbed myelination, cerebella hypoplasia, microcephaly, hydrocephaly, and lissencephaly. Recently, evidences raised from the phenotype of p73-deficient mice ... More
Opposing actions of inositol 1,4,5-trisphosphate and ryanodine receptors on nuclear factor of activated T-cells regulation in smooth muscle.
AuthorsGomez MF, Stevenson AS, Bonev AD, Hill-Eubanks DC, Nelson MT,
JournalJ Biol Chem
PubMed ID12145283
'The nuclear factor of activated T-cells (NFAT), originally identified in T-cells, has since been shown to play a role in mediating Ca(2+)-dependent gene transcription in diverse cell types outside of the immune system. We have previously shown that nuclear accumulation of NFATc3 is induced in ileal smooth muscle by platelet-derived ... More
A virus discovery method incorporating DNase treatment and its application to the identification of two bovine parvovirus species.
Authors Allander T; Emerson S U; Engle R E; Purcell R H; Bukh J;
JournalProc Natl Acad Sci U S A
PubMed ID11562506
Identification of previously unrecognized viral agents in serum or plasma samples is of great medical interest but remains a major challenge, primarily because of abundant host DNA. The current methods, library screening or representational difference analysis (RDA), are very laborious and require selected sample sets. We have developed a simple ... More
Focal Adhesion Kinase Activated by beta 4 Integrin Ligation to mCLCA1 Mediates Early Metastatic Growth.
Early metastatic growth occurs at sites of vascular arrest of blood-borne cancer cells and is entirely intravascular. Here we show that lung colonization by B16-F10 cells is licensed by beta(4) integrin adhesion to the mouse lung endothelial Ca(2+)-activated chloride channel protein mCLCA1. In a manner independent of Met, beta(4) integrin-mCLCA1-ligation ... More