The effect of a single nucleotide polymorphism on human alpha 2-antiplasmin activity.
AuthorsChristiansen VJ, Jackson KW, Lee KN, McKee PA
JournalBlood
PubMed ID17317851
'The primary inhibitor of plasmin, alpha(2)-antiplasmin (alpha(2)AP), is secreted by the liver into plasma with Met as the amino-terminus. During circulation, Met-alpha(2)AP is cleaved by antiplasmin-cleaving enzyme (APCE), yielding Asn-alpha(2)AP, which is crosslinked into fibrin approximately 13 times faster than Met-alpha(2)AP. The Met-alpha(2)AP gene codes for either Arg or Trp ... More
TAFIa, PAI-1 and alpha-antiplasmin: complementary roles in regulating lysis of thrombi and plasma clots.
AuthorsMutch NJ, Thomas L, Moore NR, Lisiak KM, Booth NA
JournalJ Thromb Haemost
PubMed ID17388801
'PAI-1 and alpha(2)-antiplasmin (alpha(2)AP) are the principal direct inhibitors of fibrinolytic proteases. Thrombin activatable fibrinolysis inhibitor (TAFI), a plasma procarboxypeptidase activated by thrombin-thrombomodulin to form TAFIa, also regulates fibrinolysis by modulating fibrin. In this study, the relative contributions of PAI-1, alpha(2)AP and TAFIa to inhibition of lysis were assessed. In ... More
Alpha-2-antiplasmin: a serpin with two separate but overlapping reactive sites.
AuthorsPotempa J, Shieh BH, Travis J
JournalScience
PubMed ID2456616
Although the proteinase inhibitor alpha-2-antiplasmin (alpha 2AP) is known to control the activity of plasmin through rapid formation of stable complexes, it also efficiently inactivates chymotrypsin. These interactions are shown to occur at adjacent, overlapping sites so that plasmin attacks the inhibitor at an Arg364-Met365 peptide bond, while chymotrypsin interacts ... More
The kidney is a major site of alpha(2)-antiplasmin production.
AuthorsMenoud PA, Sappino N, Boudal-Khoshbeen M, Vassalli JD, Sappino AP
JournalJ Clin Invest
PubMed ID8647939
The serpin alpha2-antiplasmin (alpha2-AP) is the major circulating inhibitor of plasmin; it plays a determining role in the regulation of intravascular fibrinolysis, In addition to blood plasma, plasmin formation occurs in various organs where it is thought to fulfill a spectrum of functions not restricted to clot lysis. Alpha2-AP is ... More