Periostin as a heterofunctional regulator of cardiac development and disease.
AuthorsConway SJ, Molkentin JD
JournalCurr Genomics
PubMed ID19516962
'Periostin (Postn) is a heterofunctional secreted extracellular matrix (ECM) protein comprised of four fasciclin domains that promotes cellular adhesion and movement, as well as collagen fibrillogenesis. Postn is expressed in unique growth centers during embryonic development where it facilitates epithelial-mesenchymal transition (EMT) of select cell populations undergoing reorganization. In the ... More
Periostin: novel diagnostic and therapeutic target for cancer.
AuthorsKudo Y, Siriwardena BS, Hatano H, Ogawa I, Takata T
JournalHistol Histopathol
PubMed ID17616943
'Periostin is a secreted protein that shares a structural homology to the axon guidance protein fasciclin I (FAS1) in insects and was originally named as osteoblast-specific factor-2 (Osf2). Periostin is particularly highly homologus to Betaig-h3, which promotes cell adhesion and spreading of fibroblasts. It has recently been reported that Periostin ... More
Periostin and bone marrow fibrosis.
AuthorsOku E, Kanaji T, Takata Y, Oshima K, Seki R, Morishige S, Imamura R, Ohtsubo K, Hashiguchi M, Osaki K, Yakushiji K, Yoshimoto K, Ogata H, Hamada H, Izuhara K, Sata M, Okamura T
JournalInt J Hematol
PubMed ID18465194
'Periostin is a secreted protein that shares structural homology with the insect axon guidance protein fasciclin 1. Periostin is expressed predominantly in collagen-rich fibrous connective tissues that are subjected to constant mechanical stresses. We have shown previously that periostin is a novel component of subepithelial fibrosis in bronchial asthma. Here, ... More
Functional role of periostin in development and wound repair: implications for connective tissue disease.
AuthorsHamilton DW
JournalJ Cell Commun Signal
PubMed ID18642132
'Integrity of the extracellular matrix (ECM) is essential for maintaining the normal structure and function of connective tissues. ECM is secreted locally by cells and organized into a complex meshwork providing physical support to cells, tissues, and organs. Initially thought to act only as a scaffold, the ECM is now ... More
Expression of periostin and its clinicopathological relevance in gastric cancer.
AuthorsLi JS, Sun GW, Wei XY, Tang WH
JournalWorld J Gastroenterol
PubMed ID17876898
To investigate the expression and localization of periostin in gastric cancer and its clinical relevance.
Expression of periostin in human breast cancer.
AuthorsPuglisi F, Puppin C, Pegolo E, Andreetta C, Pascoletti G, D'Aurizio F, Pandolfi M, Fasola G, Piga A, Damante G, Di Loreto C
JournalJ Clin Pathol
PubMed ID17938160
Periostin is a secreted adhesion protein, normally expressed in mesenchime-derived cells. Aberrant expression of the periostin gene in epithelial tumours seems to play a role in angiogenesis and metastases. ... More