'The co-ordinated function of effector and accessory cells in the immune system is assisted by adhesion molecules on the cell surface that stabilize interactions between different cell types. Leukocyte function-associated antigen 1 (LFA-1) is expressed on the surface of all white blood cells and is a receptor for intercellular adhesion ... More
Adhesion molecule interactions facilitate human immunodeficiency virus type 1-induced virological synapse formation between T cells.
AuthorsJolly C, Mitar I, Sattentau QJ
JournalJ Virol
PubMed ID17913807
'Human immunodeficiency virus type 1 (HIV-1) can spread between CD4+ T cells by using a virological synapse (VS). The VS assembly is a cytoskeleton-driven process dependent on HIV-1 envelope glycoprotein (Env)-receptor engagement and is hypothesized to require adhesion molecule interactions. Here we demonstrate that leukocyte function-associated antigen 1 (LFA-1), intercellular ... More
The role of ICAM expression in immunity and disease.
AuthorsSimmons DL
JournalCancer Surv
PubMed ID7553659
The ICAM family consists of three members. All are ligands for LFA1, and ICAM1 can also bind Mac1. However, the complete repertoire of other ligands has not yet been defined. The ICAMs are not functionally redundant, since they have quite distinct expression profiles and can bind LFA1 differentially. ICAM3 is ... More
CD50 (intercellular adhesion molecule-3) is expressed at higher levels on memory than on naive human T cells but induces a similar calcium mobilization on both subsets.
AuthorsPino-Otín MR, Juan M, de la Fuente MA, Viñas O, Martínez-Cáceres E, Fernández MD, Miralles A, Vilella R, Yagüe J, Vives J
JournalTissue Antigens
PubMed ID7482494
CD50, the intercellular adhesion molecule-3 (ICAM-3), is expressed almost exclusively on hematopoietic cells. T lymphocytes display a bimodal distribution on CD50 expression levels. It was observed that CD45RO+ cells expressed higher levels of CD50 than CD45RA+ T lymphocytes. A similar situation was observed when CD4 and CD8 subpopulations were analyzed, ... More