AIM1, a novel non-lens member of the betagamma-crystallin superfamily, is associated with the control of tumorigenicity in human malignant melanoma.
Authors Ray M E; Wistow G; Su Y A; Meltzer P S; Trent J M;
JournalProc Natl Acad Sci U S A
PubMed ID9096375
'AIM1 is a novel gene whose expression is associated with the experimental reversal of tumorigenicity of human malignant melanoma. The predicted protein product of the major 4.1-kb transcript shows striking similarity to the betagamma-crystallin superfamily. All known members of this superfamily contain two or four characteristic motifs arranged as one ... More
The cloning of a human ABC gene (ABC3) mapping to chromosome 16p13.3.
Authors Connors T D; Van Raay T J; Petry L R; Klinger K W; Landes G M; Burn T C;
JournalGenomics
PubMed ID9027511
The ATP binding cassette (ABC) transporters, or traffic ATPases, constitute a large family of proteins responsible for the transport of a wide variety of substrates across cell membranes in both prokaryotic and eukaryotic cells. We describe a human ABC protein with regions of strong homology to the recently described murine ... More
Identification of a cullin homology region in a subunit of the anaphase-promoting complex.
Authors Yu H; Peters J M; King R W; Page A M; Hieter P; Kirschner M W;
JournalScience
PubMed ID9469815
The anaphase-promoting complex is composed of eight protein subunits, including BimE (APC1), CDC27 (APC3), CDC16 (APC6), and CDC23 (APC8). The remaining four human APC subunits, APC2, APC4, APC5, and APC7, as well as human CDC23, were cloned. APC7 contains multiple copies of the tetratrico peptide repeat, similar to CDC16, CDC23, ... More
AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer.
Authors Anzick S L; Kononen J; Walker R L; Azorsa D O; Tanner M M; Guan X Y; Sauter G; Kallioniemi O P; Trent J M; Meltzer P S;
JournalScience
PubMed ID9252329
Members of the recently recognized SRC-1 family of transcriptional coactivators interact with steroid hormone receptors to enhance ligand-dependent transcription. AIB1, a member of the SRC-1 family, was cloned during a search on the long arm of chromosome 20 for genes whose expression and copy number were elevated in human breast ... More
Cloning, sequencing, gene organization, and localization of the human ribosomal protein RPL23A gene.
Authors Fan W; Christensen M; Eichler E; Zhang X; Lennon G;
JournalGenomics
PubMed ID9417910
The intron-containing gene for human ribosomal protein RPL23A has been cloned, sequenced, and localized. The gene is approximately 4.0 kb in length and contains five exons and four introns. All splice sites exactly match the AG/GT consensus rule. The transcript is about 0.6 kb and is detected in all tissues ... More
Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3.
Authors Burn T C; Connors T D; Van Raay T J; Dackowski W R; Millholland J M; Klinger K W; Landes G M;
JournalGenome Res
PubMed ID8828041
A 700-kb region of DNA in human chromosome 16p13.3 has been shown to contain the polycystic kidney disease 1 (PKD1) and the tuberous sclerosis type 2 (TSC2) disease genes. An estimated 20 genes are present in this region of chromosome 16. We have initiated studies to identify transcribed sequences in ... More