P38 and activating transcription factor-2 involvement in osteoblast osmotic response to elevated extracellular glucose.
AuthorsZayzafoon M, Botolin S, McCabe LR,
JournalJ Biol Chem
PubMed ID12149242
'Poorly controlled or untreated type I diabetes mellitus is characterized by hyperglycemia and is associated with decreased bone mass and osteoporosis. We have demonstrated that osteoblasts are sensitive to hyperglycemia-associated osmotic stress and respond to elevated extracellular glucose or mannitol by increasing c-jun and collagen I expression. To determine whether ... More