Clinical significance of TROP2 expression in colorectal cancer.
AuthorsOhmachi T, Tanaka F, Mimori K, Inoue H, Yanaga K, Mori M
JournalClin Cancer Res
PubMed ID16707602
'To identify cancer-related genes, the expression profiles of colorectal cancer cells and normal epithelial cells were examined and compared using laser microdissection and cDNA microarray analysis. From these combined techniques, several cancer-related genes, including TROP2, were identified. TROP2 is known as a calcium signal transducer and is highly expressed in ... More
Retroposition in a family of carcinoma-associated antigen genes.
AuthorsLinnenbach AJ, Seng BA, Wu S, Robbins S, Scollon M, Pyrc JJ, Druck T, Huebner K
JournalMol Cell Biol
PubMed ID8382772
'The gene encoding the carcinoma-associated antigen defined by the monoclonal antibody GA733 is a member of a family of at least two type I membrane proteins. This study describes the mechanism of evolution of the GA733-1 and GA733-2 genes. A full-length cDNA clone for GA733-1 was obtained by screening a ... More
Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas.
AuthorsFornaro M, Dell'Arciprete R, Stella M, Bucci C, Nutini M, Capri MG, Alberti S
JournalInt J Cancer
PubMed ID7665234
'We have cloned by expression the cDNA encoding Trop-2, a cell-surface glycoprotein expressed by most human carcinomas. Formal proof of the identity of the clone is the hybridization to DNA and RNA from genomic TROP2 transfectants. TROP2 is a single-copy gene in human cells, hybridizes to a single 1.8-kb mRNA ... More
Human Trop-2 is a tumor-associated calcium signal transducer.
AuthorsRipani E, Sacchetti A, Corda D, Alberti S
JournalInt J Cancer
PubMed ID9610724
Trop-2/EGP-1/GA733-1 is a recently identified cell surface glycoprotein highly expressed by human carcinomas. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Thus, we investigated whether Trop-2 might be a functional signaling molecule. Using the fluorescent probe Fura-2, we assayed the ... More