Bcl-2 family members regulate anoxia-induced cell death.
AuthorsShroff EH, Snyder C, Chandel NS
JournalAntioxid Redox Signal
PubMed ID17627475
The mechanisms underlying anoxia (0-0.5% oxygen)-induced cell death are not fully understood. Here we discuss the mechanisms by which cells undergo apoptosis in the absence of oxygen. Cell death during anoxia occurs via the intrinsic pathway of apoptosis. Key regulators of apoptosis during anoxia are the Bcl-2 family of proteins. ... More
Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis.
AuthorsZhou F, Yang Y, Xing D
JournalFEBS J
PubMed ID21182587
Autophagy and apoptosis play important roles in the development, cellular homeostasis and, especially, oncogenesis of mammals. They may be triggered by common upstream signals, resulting in combined autophagy and apoptosis. In other instances, they may be mutually exclusive. Recent studies have suggested possible molecular mechanisms for crosstalk between autophagy and ... More
X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death.
AuthorsMuchmore SW, Sattler M, Liang H, Meadows RP, Harlan JE, Yoon HS, Nettesheim D, Chang BS, Thompson CB, Wong SL, Ng SL, Fesik SW
JournalNature
PubMed ID8692274
THE Bcl-2 family of proteins regulate programmed cell death by an unknown mechanism. Here we describe the crystal and solution structures of a Bcl-2 family member, Bcl-xL (ref. 2). The structures consist of two central, primarily hydrophobic alpha-helices, which are surrounded by amphipathic helices. A 60-residue loop connecting helices alpha1 ... More