Carbonic anhydrase XIV in skeletal muscle: subcellular localization and function from wild-type and knockout mice.
AuthorsWetzel P, Scheibe RJ, Hellmann B, Hallerdei J, Shah GN, Waheed A, Gros G, Sly WS
JournalAm J Physiol Cell Physiol
PubMed ID17459948
'The expression of carbonic anhydrase (CA) XIV was investigated in mouse skeletal muscles. Sarcoplasmic reticulum (SR) and sarcolemmal (SL) membrane fractions were isolated from wild-type (WT) and CA XIV knockout (KO) mice. The CA XIV protein of 54 kDa was present in SR and SL membrane fractions as shown by ... More
Human carbonic anhydrase XIV (CA14): cDNA cloning, mRNA expression, and mapping to chromosome 1.
AuthorsFujikawa-Adachi K, Nishimori I, Taguchi T, Onishi S
JournalGenomics
PubMed ID10512682
A full-length cDNA clone of a human carbonic anhydrase XIV (HGMW-approved gene symbol CA14) was obtained and sequenced. The cDNA sequence was 1757 bp long and was predicted to encode a 337-amino-acid polypeptide with a molecular mass of 37.6 kDa. The deduced amino acid sequence of CA XIV showed an ... More
Carbonic anhydrases CA4 and CA14 both enhance AE3-mediated Cl--HCO3- exchange in hippocampal neurons.
AuthorsSvichar N, Waheed A, Sly WS, Hennings JC, Hübner CA, Chesler M
JournalJ Neurosci
PubMed ID19279262
Carbonic anhydrase (CA) activity in the brain extracellular space is attributable mainly to isoforms CA4 and CA14. In brain, these enzymes have been studied mostly in the context of buffering activity-dependent extracellular pH transients. Yet evidence from others has suggested that CA4 acts in a complex with anion exchangers (AEs) ... More