Long CTG.CAG repeats from myotonic dystrophy are preferred sites for intermolecular recombination.
Authors Pluciennik Anna; Iyer Ravi R; Napierala Marek; Larson Jacquelynn E; Filutowicz Marcin; Wells Robert D;
JournalJ Biol Chem
PubMed ID12087090
Homologous recombination was shown to enable the expansion of CTG.CAG repeat sequences. Other prior investigations revealed the involvement of replication and DNA repair in these genetic instabilities. Here we used a genetic assay to measure the frequency of homologous intermolecular recombination between two CTG.CAG tracts. When compared with non-repeating sequences ... More