Biochemistry of mitochondrial nitric-oxide synthase.
AuthorsElfering SL, Sarkela TM, Giulivi C
JournalJ Biol Chem
PubMed ID12154090
We reported that the generation of nitric oxide by mitochondria is catalyzed by a constitutive, mitochondrial nitric-oxide synthase (mtNOS). Given that this production may establish the basis for a novel regulatory pathway of energy metabolism, oxygen consumption, and oxygen free radical production, it becomes imperative to identify unequivocally and characterize ... More