Association of Bcr-Abl with the Proto-oncogene Vav Is Implicated in Activation of the Rac-1 Pathway.
Authors: Bassermann Florian; Jahn Thomas; Miething Cornelius; Seipel Petra; Bai Ren-Yuan; Coutinho Sunita; Tybulewicz Victor L; Peschel Christian; Duyster Justus;
Journal:J Biol Chem
PubMed ID:11790798
'Vav is a guanine nucleotide exchange factor for the Rho/Rac family predominantly expressed in hematopoietic cells and implicated in cell proliferation and cytoskeletal organization. The oncogenic tyrosine kinase Bcr-Abl has been shown to activate Rac-1, which is important for Bcr-Abl induced leukemogenesis. Previous studies by Matsuguchi et al. (Matsuguchi, T., ... More
The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity.
Authors: Qu Dianbo; Li Qing; Lim Hui-Ying; Cheung Nam Sang; Li Rong; Wang Jerry H; Qi Robert Z;
Journal:J Biol Chem
PubMed ID:11741927
'The neuronal Cdk5 kinase is composed of the catalytic subunit Cdk5 and the activator protein p35(nck5a) or its isoform, p39(nck5ai). To identify novel p35(nck5a)- and p39(nck5ai)-binding proteins, fragments of p35(nck5a) and p39(nck5ai) were utilized in affinity isolation of binding proteins from rat brain homogenates, and the isolated proteins were identified ... More
Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth.
Authors:Ozeki Y, Tomoda T, Kleiderlein J, Kamiya A, Bord L, Fujii K, Okawa M, Yamada N, Hatten ME, Snyder SH, Ross CA, Sawa A,
Journal:Proc Natl Acad Sci U S A
PubMed ID:12506198
Disrupted-in-Schizophrenia-1 (DISC-1) is a gene whose mutant truncation is associated with major psychiatric illness with a predominance of schizophrenic symptomatology. We have cloned and characterized rodent DISC-1. DISC-1 expression displays pronounced developmental regulation with the highest levels in late embryonic life when the cerebral cortex develops. In yeast two-hybrid analyses, ... More
KRIT1, a gene mutated in cerebral cavernous malformation, encodes a microtubule-associated protein.
Authors: Gunel Murat; Laurans Maxwell S H; Shin Dana; DiLuna Michael L; Voorhees Jennifer; Choate Keith; Nelson-Williams Carol; Lifton Richard P;
Journal:Proc Natl Acad Sci U S A
PubMed ID:12140362
Mutations in Krev1 interaction trapped gene 1 (KRIT1) cause cerebral cavernous malformation, an autosomal dominant disease featuring malformation of cerebral capillaries resulting in cerebral hemorrhage, strokes, and seizures. The biological functions of KRIT1 are unknown. We have investigated KRIT1 expression in endothelial cells by using specific anti-KRIT1 antibodies. By both ... More