TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2.
Authors Li Xiaoming; Yang Yili; Ashwell Jonathan D;
JournalNature
PubMed ID11907583
Tumour necrosis factor-alpha (TNF-alpha) is a proinflammatory mediator that exerts its biological functions by binding two TNF receptors (TNF-RI and TNF-RII), which initiate biological responses by interacting with adaptor and signalling proteins. Among the signalling components that associate with TNF receptors are members of the TNF-R-associated factor (TRAF) family. TRAF2 ... More