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Invitrogen
CD63 Monoclonal Antibody (Ts63)
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FIGURE: 1 / 97
CD63 Antibody (10628D) in WB
International journal of oncology 2023 -
Morphology, size distribution, concentration and protein profiles of exosomes from HNSCC cell lines. Supernatants from HNSCC cell lines were collected and exosomes were isolated on mini-size exclusion chromatography columns. (A) Exosomes from UM-SCC-11B (11B), UM-SCC-14C (14C) and UM-SCC-22B (22B) show the typical vesicular shape and size in TEM images. Scale bar, 100 nm. (B) Western blotting was performed ... View More
Product Details
10628D
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
C. elegans,
Human,
Mouse,
Pig
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
Ts63
Immunogen
CD63 purified from Jurkat and HEL cells
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
purified
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Shipping conditions
Ambient
RRID
Product Specific Information
Tested in western blotting under non-reducing conditions.
Target Information
CD63, also known as LAMP-3, is a glycoprotein belonging to the tetraspanin family, primarily located in late endosomes, lysosomes, and secretory vesicles across various cell types. It is expressed intracellularly in resting platelets and basophils, but upon activation, CD63 translocates to the plasma membrane, making it a widely used marker for basophil activation. Unlike basophils, mast cells can expose CD63 without activation. CD63 is expressed on activated platelets, monocytes, macrophages, and granulocytes, as well as endothelial cells, fibroblasts, and smooth muscle cells. It interacts with integrins (such as VLA-3 and VLA-6) and TIMP-1, playing roles in mediating allergic responses, phagocytosis, and cell migration. Additionally, CD63 is involved in the regulation of H/K-ATPase trafficking and ROMK1 channels, and serves as a T-cell costimulation molecule. CD63 expression can be used to predict prognosis in early-stage carcinomas and is identical to the melanoma-associated antigen ME491 and the platelet antigen PTLGP40. Diseases associated with CD63 dysfunction include melanoma and Hermansky-Pudlak Syndrome, highlighting its significance in both immune responses and disease processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD 63; CD63; CD63 antigen; CD63 antigen (melanoma 1 antigen); Granulophysin; LAMP-3; Limp1; Lysosomal-associated membrane protein 3; Lysosome integral membrane protein 1; lysosome-associated membrane glycoprotein 3; Melanoma-associated antigen ME491; melanoma-associated antigen MLA1; Ocular melanoma-associated antigen; OMA81H; Tetraspanin-30; Tspan-30
Gene Aliases: CD63; LAMP-3; ME491; MLA1; OMA81H; TSPAN30
UniProt ID: (Human) P08962
Entrez Gene ID: (Human) 967
positive regulation of receptor internalization
platelet degranulation
cell-matrix adhesion
negative regulation of epithelial cell migration
protein transport
cell migration
epithelial cell differentiation
cellular protein localization
endosome to melanosome transport
positive regulation of cell adhesion
pigment granule maturation
regulation of vascular endothelial growth factor signaling pathway
regulation of rubidium ion transport
positive regulation of integrin-mediated signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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