Signal transduction by tumor necrosis factor mediated by JNK protein kinases.
AuthorsSluss HK, Barrett T, Dérijard B, Davis RJ
JournalMol Cell Biol
PubMed ID7969172
'JNK protein kinases are distantly related to mitogen-activated protein kinases (ERKs) and are activated by dual phosphorylation on Tyr and Thr. The JNK protein kinase group includes the 46-kDa isoform JNK1. Here we describe the molecular cloning of a second member of the JNK group, the 55-kDa protein kinase JNK2. ... More
Selective interaction of JNK protein kinase isoforms with transcription factors.
'The JNK protein kinase is a member of the MAP kinase group that is activated in response to dual phosphorylation on threonine and tyrosine. Ten JNK isoforms were identified in human brain by molecular cloning. These protein kinases correspond to alternatively spliced isoforms derived from the JNK1, JNK2 and JNK3 ... More
Signal transduction by the JNK group of MAP kinases.
AuthorsDavis RJ
JournalCell
PubMed ID11057897
JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation.
AuthorsKallunki T, Su B, Tsigelny I, Sluss HK, Dérijard B, Moore G, Davis R, Karin M
JournalGenes Dev
PubMed ID8001819
The transcriptional activity of c-Jun is augmented through phosphorylation at two sites by a c-Jun amino-terminal kinase (JNK). All cells express two distinct JNK activities, 46 and 55 kD in size. It is not clear which of them is the more important c-Jun kinase and how they specifically recognize c-Jun. ... More