Sense and antisense cDNA transfection of CD36 (glycoprotein IV) in melanoma cells. Role of CD36 as a thrombospondin receptor.
AuthorsSilverstein RL, Baird M, Lo SK, Yesner LM
JournalJ Biol Chem
PubMed ID1379600
'Thrombospondin (TSP) is a multifunctional matrix and platelet glycoprotein that interacts with cell surfaces and may play a role in mediating cell adhesion, platelet aggregation, platelet-monocyte interactions, cell proliferation, angiogenesis, tumor metastasis, and protease generation. To clarify and confirm the function of CD36 (glycoprotein IV) as a TSP receptor, we ... More
CD36: a multiligand molecule.
AuthorsGe Y, Elghetany MT
JournalLab Hematol
PubMed ID15790550
'CD36 is a multiligand receptor associated with a broad array of physiological processes and involved in markedly diverse disorders, including atherosclerosis, insulin resistance and diabetes, dyslipidemia, tumor angiogenesis, and host defense against Plasmodium falciparum. CD36 deficiency has proved to be common, particularly in ethnic groups such as African Americans and ... More
CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes.
AuthorsOquendo P, Hundt E, Lawler J, Seed B
JournalCell
PubMed ID2473841
Erythrocytes infected with P. falciparum express knob-like adhesion structures that allow the infected cells to cling to the postcapilliary endothelium of characteristic host organs. At present, the mechanism of cytoadherence is not fully understood. While parasitized erythrocytes have been shown to specifically bind to the platelet/matrix molecule thrombospondin, adherence to ... More
Identification of glycoprotein IV (CD36) as a primary receptor for platelet-collagen adhesion.
AuthorsTandon NN, Kralisz U, Jamieson GA
JournalJ Biol Chem
PubMed ID2468670
The role of glycoprotein IV (GPIV) in platelet activation processes has been examined by several different approaches: (i) Fab fragments of a monospecific polyclonal antibody to purified platelet GPIV (approximately 20 micrograms/ml) completely inhibited platelet shape change, aggregation, and secretion induced by collagen. Aggregation and secretion by ADP (but not ... More