2B4/CD48-mediated regulation of lymphocyte activation and function.
AuthorsAssarsson E, Kambayashi T, Persson CM, Chambers BJ, Ljunggren HG
JournalJ Immunol
PubMed ID16081768
2B4 (CD244) is a member of the CD2 subset of the Ig superfamily. This molecule is expressed on innate immune cells, including NK cells, and on subsets of T cells. The 2B4 molecule interacts with CD48, which is widely expressed on hemopoietic cells. Although earlier reports demonstrated a role for ... More
Fine-tuning of immune responses by SLAM-related receptors.
AuthorsBhat R, Eissmann P, Endt J, Hoffmann S, Watzl C
JournalJ Leukoc Biol
PubMed ID16365151
The modulation of antigen receptor signals is important for a productive immune response. The main function of the recently identified members of the signaling lymphocyte activating molecule (SLAM)-related receptors (SRR) is the fine-tuning of immune cell activation. Disruption of SRR function is the cause for severe immune disorders such as ... More
The role of glycosyl phosphatidyl inositol (GPI)-anchored cell surface proteins in T-cell activation.
AuthorsLoertscher R, Lavery P
JournalTranspl Immunol
PubMed ID12180852
Glycosylphosphatidylinositol (GPI)-anchored cell surface proteins are widely expressed in tissues, including cells of immunohematopoietic origin. Cross-linking of GPI-linked proteins on T lymphocytes, such as Thy-1 (CD90), Ly-6 A/E, CD48, CD59 and others, induces T-cell mitogenesis. Similar to cross-linking with T-cell receptor (TcR)-specific antibodies, ligation of GPI-anchored proteins induces an intracellular ... More
A ligand for human CD48 on epithelial cells.
AuthorsIanelli CJ, Edson CM, Thorley-Lawson DA
JournalJ Immunol
PubMed ID9378979
CD48 is a member of the Ig superfamily with a high degree of sequence homology to CD58 (LFA-3). In rodents, CD48 is the ligand for CD2 whereas in humans, CD58 is the ligand for CD2. Despite intensive efforts, no ligand for human CD48 has been convincingly demonstrated. We now show ... More
Structure, expression, and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen. Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3.
AuthorsWong YW, Williams AF, Kingsmore SF, Seldin MF
JournalJ Exp Med
PubMed ID1693656
The mouse BCM1 (OX45, Blast-1) antigen has been cDNA cloned and sequenced to provide data supporting the view that BCM1, LFA3, and CD2 constitute a subgroup within the Ig superfamily. Mouse BCM1 is widely expressed on leukocytes and is likely to be anchored to the cell surface by a glycosyl-phosphatidylinositol ... More