Granulins, a novel class of peptide from leukocytes.
AuthorsBateman A, Belcourt D, Bennett H, Lazure C, Solomon S
JournalBiochem Biophys Res Commun
PubMed ID2268320
'We report the isolation and characterization of a novel class of leukocyte peptides with possible cytokine-like activities which we call granulins. They are cystine-rich with molecular weights of approximately 6 Kda, except for granulin D, which appears to be a dimer. We present the sequence of one member of this ... More
E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3.
AuthorsZhou Y, Li L, Liu Q, Xing G, Kuai X, Sun J, Yin X, Wang J, Zhang L, He F
JournalCell Signal
PubMed ID18276110
'Tribbles 3 homolog (TRB3) is recently identified as a scaffold-like regulator of various signal transducers and has been implicated in several processes including insulin signaling, NF-kappaB signaling, lipid metabolism and BMP signaling. To further understand cellular mechanisms of TRB3 regulation, we performed a yeast two-hybrid screen to identify novel TRB3 ... More
Granulin and granulin repeats interact with the Tat.P-TEFb complex and inhibit Tat transactivation.
AuthorsHoque M, Tian B, Mathews MB, Pe'ery T
JournalJ Biol Chem
PubMed ID15653695
'The cellular positive transcription elongation factor b (P-TEFb), containing cyclin T1 and cyclin-dependent kinase 9 (CDK9), interacts with the human immunodeficiency virus, type 1 (HIV-1) regulatory protein Tat to enable viral transcription and replication. Cyclin T1 is an unusually long cyclin and is engaged by cellular regulatory proteins. Previous studies ... More
The growth factor granulin interacts with cyclin T1 and modulates P-TEFb-dependent transcription.
AuthorsHoque M, Young TM, Lee CG, Serrero G, Mathews MB, Pe'ery T
JournalMol Cell Biol
PubMed ID12588988
Cyclin T1, together with the kinase CDK9, is a component of the transcription elongation factor P-TEFb which binds the human immunodeficiency virus type 1 (HIV-1) transactivator Tat. P-TEFb facilitates transcription by phosphorylating the carboxy-terminal domain (CTD) of RNA polymerase II. Cyclin T1 is an exceptionally large cyclin and is therefore ... More