Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1.
Authors Jones Brandi C; Logsdon Naomi J; Josephson Kristopher; Cook Jennifer; Barry Peter A; Walter Mark R;
JournalProc Natl Acad Sci U S A
PubMed ID12093920
'Human IL-10 (hIL-10) modulates critical immune and inflammatory responses by way of interactions with its high- (IL-10R1) and low-affinity (IL-10R2) cell surface receptors. Human cytomegalovirus exploits the IL-10 signaling pathway by expressing a functional viral IL-10 homolog (cmvIL-10), which shares only 27% sequence identity with hIL-10 yet signals through IL-10R1 ... More