Interleukin 7 reduces the levels of spontaneous apoptosis in CD4+ and CD8+ T cells from HIV-1-infected individuals.
AuthorsVassena L, Proschan M, Fauci AS, Lusso P,
JournalProc Natl Acad Sci U S A
PubMed ID17284597
'Apoptosis has been suggested as one of the major mechanisms of CD4+ T cell depletion during the course of HIV type 1 (HIV-1) infection. Here, we show that interleukin 7 (IL-7), a nonredundant cytokine that plays essential roles in the generation and homeostasis of the T cell compartment of the ... More
Characterization of naturally occurring CD4+CD25+ regulatory T cells in rhesus monkeys.
AuthorsHaanstra KG, van der Maas MJ, 't Hart BA, Jonker M
JournalTransplantation
PubMed ID18431240
Translational research in a relevant preclinical model is recommended before Treg-inducing protocols can be implemented in humans. We have characterized rhesus monkey CD25 cells phenotypically and functionally. ... More
T cells modulate Epstein-Barr virus latency phenotypes during infection of humanized mice.
AuthorsHeuts F, Rottenberg ME, Salamon D, Rasul E, Adori M, Klein G, Klein E, Nagy N,
Journal
PubMed ID24390326
Human B cells, the main target of Epstein-Barr virus (EBV), can display several types of latent viral protein expression, denoted 0, I, IIa, IIb, or III. Of these, only type III expression induces proliferation of cells in vitro. These latency types are present at specific stages of infection and are ... More
Filamin B mediates ICAM-1-driven leukocyte transendothelial migration.
AuthorsKanters E, van Rijssel J, Hensbergen PJ, Hondius D, Mul FP, Deelder AM, Sonnenberg A, van Buul JD, Hordijk PL,
JournalJ Biol Chem
PubMed ID18809679
During inflammation, the endothelium mediates rolling and firm adhesion of activated leukocytes. Integrin-mediated adhesion to endothelial ligands of the Ig-superfamily induces intracellular signaling in endothelial cells, which promotes leukocyte transendothelial migration. We identified the actin cross-linking molecule filamin B as a novel binding partner for intracellular adhesion molecule-1 (ICAM-1). Immune ... More