'The S100 gene family comprises more than 20 members whose protein sequences encompass at least one EF-hand Ca2+ binding motif. The expression of individual family members is not ubiquitous for all tissues and there appears to be an element of tissue-specific expression. Molecular analysis of breast tumors has revealed that ... More
Psoriasin (S100A7).
AuthorsWatson PH, Leygue ER, Murphy LC
JournalInt J Biochem Cell Biol
PubMed ID9693957
'Psoriasin (S100A7) is a relatively new member of the S100 gene family that is located within the S100 gene cluster on chromosome 1q21 and shares the typical calcium binding domains that define this family of proteins. It was first identified as a 11.4 kDa cytoplasmic and secreted protein isolated from ... More
S100A11, a putative tumor suppressor gene, is overexpressed in pancreatic carcinogenesis.
AuthorsOhuchida K, Mizumoto K, Ohhashi S, Yamaguchi H, Konomi H, Nagai E, Yamaguchi K, Tsuneyoshi M, Tanaka M
JournalClin Cancer Res
PubMed ID17000675
Recent microarray analyses revealed that expression of S100A11 is up-regulated in pancreatic cancer. The aim of the present study was to evaluate the association of S100A11 with pancreatic carcinogenesis. ... More
The structure of S100A11 fragment explains a local structural change induced by phosphorylation.
AuthorsKouno T, Mizuguchi M, Sakaguchi M, Makino E, Mori Y, Shinoda H, Aizawa T, Demura M, Huh NH, Kawano K
JournalJ Pept Sci
PubMed ID18618420
S100A11 protein is a member of the S100 family containing two EF-hand motifs. It undergoes phosphorylation on residue T10 after cell stimulation such as an increase in Ca(2+) concentration. Phosphorylated S100A11 can be recognized by its target protein, nucleolin. Although S100A11 is initially expressed in the cytoplasm, it is transported ... More
In vitro antimicrobial activity of the human neutrophil cytosolic S-100 protein complex, calprotectin, against Capnocytophaga sputigena.
AuthorsMiyasaki KT, Bodeau AL, Murthy AR, Lehrer RI
JournalJ Dent Res
PubMed ID8423249
Calprotectin is a complex of two anionic proteins found in abundance in the cytosol of neutrophils, certain macrophages, and oral epithelial keratinocytes. Bacteria of the genus Capnocytophaga are pathogens of periodontal origin which can cause systemic infection in neutropenic subjects. Recently, it has been observed that Capnocytophaga may be internalized ... More
Identification and characterization of binding sites on S100A7, a participant in cancer and inflammation pathways.
AuthorsLeón R, Murray JI, Cragg G, Farnell B, West NR, Pace TC, Watson PH, Bohne C, Boulanger MJ, Hof F
JournalBiochemistry
PubMed ID19810752
S100A7 (psoriasin) is a member of the S100 family of signaling proteins. It is implicated in and considered a therapeutic target for inflammation and cancer, yet no small molecule ligands for S100A7 have been identified. To begin the development of specific small molecule inhibitors of S100A7 function, we have used ... More