Lysosome-associated membrane proteins h-LAMP1 (CD107a) and h-LAMP2 (CD107b) are activation-dependent cell surface glycoproteins in human peripheral blood mononuclear cells which mediate cell adhesion to vascular endothelium.
AuthorsKannan K, Stewart RM, Bounds W, Carlsson SR, Fukuda M, Betzing KW, Holcombe RF
JournalCell Immunol
PubMed ID8660832
'Lysosome-associated membrane proteins (LAMPs) are transmembrane lysosomal glycoproteins which are detectable at the cell surface of lymphocytes in patients with scleroderma and systemic lupus erythematosus. While these proteins have been shown to mediate adhesion of tumor cells to vascular endothelial selectins, the function of LAMPs expressed at the cell surface ... More
CD107a (LAMP-1) and CD107b (LAMP-2).
AuthorsChang MH, Karageorgos LE, Meikle PJ
JournalJ Biol Regul Homeost Agents
PubMed ID12144129
Immunochemical analysis of CD107a (LAMP-1).
AuthorsParkinson-Lawrence EJ, Dean CJ, Chang M, Hopwood JJ, Meikle PJ, Brooks DA
JournalCell Immunol
PubMed ID16168398
CD107a, also known as the lysosome associated membrane protein-1 (LAMP-1), is expressed largely in the endosome-lysosome membranes of cells, but is also found on the plasma membrane (1-2% of total LAMP-1). LAMP-1 has been implicated in a variety of cellular functions, including cancer metastasis. It has been proposed as a ... More