Ets-1 positively regulates Fas ligand transcription via cooperative interactions with Sp1.
AuthorsKavurma MM, Bobryshev Y, Khachigian LM,
JournalJ Biol Chem
PubMed ID11970950
'The FasL/Fas system has been implicated in smooth muscle cell apoptosis and atherosclerotic plaque instability, a process that can lead to plaque rupture, precipitating myocardial infarction and sudden death. The transcriptional mechanisms regulating FasL gene expression in vascular smooth muscle cells are poorly understood. We recently described a novel mechanism ... More
Intracellular third loop domain of angiotensin II type-2 receptor. Role in mediating signal transduction and cellular function.
Authors Hayashida W; Horiuchi M; Dzau V J;
JournalJ Biol Chem
PubMed ID8703004
'The present study tests the hypothesis that the unique intracellular third loop domain of angiotensin II type-2 (AT2) receptor is essential for the subsequent intracellular signaling and plays an important role in mediating receptor function. Synthetic intracellular third loop peptide of the AT2 receptor (AT2-3LP, 22 amino acids) and control ... More