The cadherin superfamily: diversity in form and function.
AuthorsAngst BD, Marcozzi C, Magee AI
JournalJ Cell Sci
PubMed ID11171368
'Over recent years cadherins have emerged as a growing superfamily of molecules, and a complex picture of their structure and their biological functions is becoming apparent. Variation in their extracellular region leads to the large potential for recognition properties of this superfamily. This is demonstrated strikingly by the recently discovered ... More
Cadherin-17 is required to maintain pronephric duct integrity during zebrafish development.
AuthorsHorsfield J, Ramachandran A, Reuter K, LaVallie E, Collins-Racie L, Crosier K, Crosier P
JournalMech Dev
PubMed ID12049763
We have isolated a zebrafish cadherin that is orthologous to human LI-cadherin (CDH17). Zebrafish cdh17 is expressed exclusively in the pronephric ducts during embryogenesis, and in the mesonephros during larval development and adulthood. Like its mammalian ortholog, cdh17 is also expressed in liver and intestine in adult zebrafish. We show ... More
Clinicopathological significant and prognostic influence of cadherin-17 expression in gastric cancer.
AuthorsIto R, Oue N, Yoshida K, Kunimitsu K, Nakayama H, Nakachi K, Yasui W
JournalVirchows Arch
PubMed ID16044349
Cadherin-17 (CDH17), also called liver-intestine cadherin, is a structurally unique member of the cadherin superfamily. Our serial analysis of gene expression demonstrated that CDH17 was one of the most up-regulated genes in advanced gastric carcinomas. CDH17 expression is known to be regulated by Cdx2. In the present study, we examined ... More
VE-cadherin is not required for the formation of nascent blood vessels but acts to prevent their disassembly.
AuthorsCrosby CV, Fleming PA, Argraves WS, Corada M, Zanetta L, Dejana E, Drake CJ
JournalBlood
PubMed ID15604224
We investigated the role of vascular endothelial (VE)-cadherin in blood vessel morphogenesis and established a temporal correlation linking the failure in vessel morphogenesis in VE-cadherin null embryos to a specific step in vasculogenesis. We showed that the sequence in which blood vessels failed followed the order in which they had ... More
Lifetime measurements reveal kinetic differences between homophilic cadherin bonds.
AuthorsBayas MV, Leung A, Evans E, Leckband D
JournalBiophys J
PubMed ID16326909
Cadherins are multidomain adhesion proteins whose interactions direct cell sorting during histogenesis. They determine cell adhesion specificity, but prior studies failed to identify physical differences that could underlie cell sorting. These single molecule studies identify kinetic and strength differences between different cadherins. They further demonstrate that the modular extracellular architecture ... More
Cadherin-mediated cell adhesion and tissue segregation: qualitative and quantitative determinants.
AuthorsDuguay D, Foty RA, Steinberg MS
JournalDev Biol
PubMed ID12645933
It is widely held that segregation of tissues expressing different cadherins results from cadherin-subtype-specific binding specificities. This belief is based largely upon assays in which cells expressing different cadherin subtypes aggregate separately when shaken in suspension. In various combinations of L cells expressing NCAM, E-, P-, N-, R-, or B-cadherin, ... More
Molecular evolution of the cadherin superfamily.
AuthorsHulpiau P, van Roy F
JournalInt J Biochem Cell Biol
PubMed ID18848899
This review deals with the large and pleiotropic superfamily of cadherins and its molecular evolution. We compiled literature data and an in-depth phylogenetic analysis of more than 350 members of this superfamily from about 30 species, covering several but not all representative branches within metazoan evolution. We analyzed the sequence ... More