Positive and negative regulation of APP amyloidogenesis by sumoylation.
AuthorsLi Y, Wang H, Wang S, Quon D, Liu YW, Cordell B,
JournalProc Natl Acad Sci U S A
PubMed ID12506199
'Amyloid beta peptide (Abeta) generated from amyloid precursor protein (APP) is central to Alzheimer''s disease (AD). Signaling pathways affecting APP amyloidogenesis play critical roles in AD pathogenesis and can be exploited for therapeutic intervention. Here, we show that sumoylation, covalent modification of cellular proteins by small ubiquitin-like modifier (SUMO) proteins, ... More
Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.
AuthorsKovacs DM, Fausett HJ, Page KJ, Kim TW, Moir RD, Merriam DE, Hollister RD, Hallmark OG, Mancini R, Felsenstein KM, Hyman BT, Tanzi RE, Wasco W
JournalNat Med
PubMed ID8574969
Mutations in two recently identified genes appear to cause the majority of early-onset familial Alzheimer's disease (FAD). These two novel genes, presenilin 1 (PS1) and presenilin 2 (PS2) are members of an evolutionarily conserved gene family. The normal biological role(s) of the presenilins and the mechanism(s) by which the FAD-associated ... More