IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells.
AuthorsKimura A, Naka T, Kishimoto T,
JournalProc Natl Acad Sci U S A
PubMed ID17623780
'CD4(+) T cells producing IL-17 [T helper (Th)17], as distinct from Th1 or Th2 cells, have recently been shown to be associated with autoimmunity, but it is not entirely clear how Th17 cells are generated from naïve T cells. We demonstrate here that IL-6, but not TNF-alpha or IL-1beta, can, ... More