Immunotransplantation preferentially expands T-effector cells over T-regulatory cells and cures large lymphoma tumors.
AuthorsBrody JD, Goldstein MJ, Czerwinski DK, Levy R,
JournalBlood
PubMed ID18812472
Ex vivo-expanded tumor-infiltrating lymphocytes infused into lymphodepleted recipients has clear antitumor efficacy. More practical sources of such antitumor lymphocytes would broaden the application of this approach. Previously, we described an in situ vaccination combining chemotherapy with intratumoral injection of CpG-enriched oligonucleotides, which induced T-cell immunity against established lymphoma. An ongoing ... More