Structures of the human rad17-replication factor C and checkpoint rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy.
Authors Griffith Jack D; Lindsey-Boltz Laura A; Sancar Aziz;
JournalJ Biol Chem
PubMed ID11907025
Human checkpoint Rad proteins are thought to function as damage sensors in the DNA damage checkpoint response pathway. The checkpoint proteins hRad9, hHus1, and hRad1 have limited homology to the replication processivity factor proliferating cell nuclear antigen (PCNA), and hRad17 has homology to replication factor C (RFC). Such observations have ... More