Identification and characterization of a novel member of olfactomedin-related protein family, hGC-1, expressed during myeloid lineage development.
AuthorsZhang J, Liu WL, Tang DC, Chen L, Wang M, Pack SD, Zhuang Z, Rodgers GP
JournalGene
PubMed ID11867215
We have cloned a novel hematopoietic granulocyte colony-stimulating factor (G-CSF)-induced olfactomedin-related glycoprotein, termed hGC-1 (human G-CSF-stimulated clone-1). mRNA differential display was used in conjunction with a modified two-phase liquid culture system. Cultures were enriched for early precursors of erythroid, myeloid, and megakaryocytic lineages, which were isolated after induction with erythropoietin, ... More
OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells.
Authorsvan der Flier LG, Haegebarth A, Stange DE, van de Wetering M, Clevers H
JournalGastroenterology
PubMed ID19450592
GW112, a novel antiapoptotic protein that promotes tumor growth.
AuthorsZhang X, Huang Q, Yang Z, Li Y, Li CY
JournalCancer Res
PubMed ID15059901
GW112 is a novel gene that has little homology to other known genes. It is overexpressed in a number of human tumor types, especially in those of the digestive system. We show here that GW112 is associated with GRIM-19, a protein known to be involved in regulating cellular apoptosis. Functionally, ... More
Olfactomedin 4 promotes S-phase transition in proliferation of pancreatic cancer cells.
AuthorsKobayashi D, Koshida S, Moriai R, Tsuji N, Watanabe N
JournalCancer Sci
PubMed ID17270022
Induction of olfactomedin 4 (OLFM4(GW112/hGC-1)) in cancer cells was recently reported to have a novel antiapoptotic action via binding to the potent apoptosis inducer GRIM-19. We sought to clarify undiscovered functions of constitutively expressed OLFM4 in cancer cells. OLFM4 mRNA was highly expressed in pancreatic cancer tissues. In PANC-1 cell ... More