Sulfation through the looking glass--recent advances in sulfotransferase research for the curious.
AuthorsCoughtrie MW
JournalPharmacogenomics J
PubMed ID12439736
Members of the cytosolic sulfotransferase (SULT) superfamily catalyse the sulfation of a multitude of xenobiotics, hormones and neurotransmitters. Humans have at least 10 functional SULT genes, and a number of recent advances reviewed here have furthered our understanding of SULT function. Analysis of expression patterns has shown that sulfotransferases are ... More
Sulfotransferases in the bioactivation of xenobiotics.
AuthorsGlatt H
JournalChem Biol Interact
PubMed ID11154739
Conjugation of xenobiotics is often associated with detoxification. However, this traditional view is one-sided. In particular, numerous compounds are known that are metabolized to chemically reactive metabolites via sulfation (O-sulfonation). This can be rationalized by the fact that the sulfate group is electron-withdrawing and may be cleaved off heterolytically in ... More
Structure, function and polymorphism of human cytosolic sulfotransferases.
AuthorsLindsay J, Wang LL, Li Y, Zhou SF
JournalCurr Drug Metab
PubMed ID18288952
The sulfotransferase (SULTs) catalyzes the sulfonation of a multitude of xenobiotics, hormones and neurotransmitters. This review has summarised the SULT family in detail, the structure of the twelve known enzymes, in their four known groups (SULT1, SULT2, SULT4, and SULT6) and the substrates for each respective SULT. Hepatic sulfonation is ... More
Regulation of sulfotransferase mRNA expression in male and female rats of various ages.
AuthorsKlaassen CD, Liu L, Dunn RT
JournalChem Biol Interact
PubMed ID9566754
Sulfotransferases (SULTs) are Phase II drug-metabolizing enzymes that catalyze the addition of a sulfuryl moiety to both endogenous compounds, including steroids and neurotransmitters, and certain xenobiotics, including N-hydroxy-2-acetylaminoflourine and phenolic compounds, like alpha-naphthol. In contrast to certain Phase I drug-metabolizing enzymes, little is known about the regulation of the sulfotransferases. ... More
Pharmacogenetics of soluble sulfotransferases (SULTs).
AuthorsGlatt H, Meinl W
JournalNaunyn Schmiedebergs Arch Pharmacol
PubMed ID14600802
Soluble sulfotransferases (SULTs) transfer the sulfo group from the cofactor 5'-phosphoadenosine-3'-phosphosulfate (PAPS) to nucleophilic sites of relatively small acceptor molecules including various hormones and numerous xenobiotics. Sulfo conjugation of xenobiotics can lead to the formation of polar, excretable products as well as reactive, potentially mutagenic and carcinogenic metabolites. Ten SULT ... More