Localization of the secretory granule marker protein chromogranin B in the nucleus. Potential role in transcription control.
Authors Yoo Seung Hyun; You Soon Hee; Kang Moon Kyung; Huh Yang Hoon; Lee Choong Sik; Shim Chan Seob;
JournalJ Biol Chem
PubMed ID11854265
'Chromogranins A (CGA) and B (CGB) are two major Ca(2+) storage proteins of the secretory granules of neuroendocrine cells. Nevertheless, we found in the present study that CGB was also localized in the nucleus. In immunogold electron microscopy using bovine adrenal medullary chromaffin cells, it was found that the number ... More
A gnotobiotic transgenic mouse model for studying interactions between small intestinal enterocytes and intraepithelial lymphocytes.
AuthorsMysorekar IU, Lorenz RG, Gordon JI,
JournalJ Biol Chem
PubMed ID12138109
The mouse intestinal epithelium undergoes continuous renewal throughout life. Intraepithelial lymphocytes (IELs) represent a significant fraction of this epithelium and play an important role in intestinal mucosal barrier function. We have generated a germ-free transgenic mouse model to examine the effects of a genetically engineered proliferative abnormality in the principal ... More
Floral responses to photoperiod are correlated with the timing of rhythmic expression relative to dawn and dusk in Arabidopsis.
Authors Roden Laura C; Song Hae-Ryong; Jackson Stephen; Morris Karl; Carre Isabelle A;
JournalProc Natl Acad Sci U S A
PubMed ID12271123
Daylength, or photoperiod, is perceived as a seasonal signal for the control of flowering of many plants. The measurement of daylength is thought to be mediated through the interaction of phototransduction pathways with a circadian rhythm, so that flowering is induced (in long-day plants) or repressed (in short-day plants) when ... More