TDAG51 is an ERK signaling target that opposes ERK-mediated HME16C mammary epithelial cell transformation.
AuthorsOberst MD, Beberman SJ, Zhao L, Yin JJ, Ward Y, Kelly K,
JournalBMC Cancer
PubMed ID18597688
'INTRODUCTION: Signaling downstream of Ras is mediated by three major pathways, Raf/ERK, phosphatidylinositol 3 kinase (PI3K), and Ral guanine nucleotide exchange factor (RalGEF). Ras signal transduction pathways play an important role in breast cancer progression, as evidenced by the frequent over-expression of the Ras-activating epidermal growth factor receptors EGFR and ... More