The lspA gene, encoding the type II signal peptidase of Rickettsia typhi: transcriptional and functional analysis.
AuthorsRahman MS, Ceraul SM, Dreher-Lesnick SM, Beier MS, Azad AF,
JournalJ Bacteriol
PubMed ID17098907
'Lipoprotein processing by the type II signal peptidase (SPase II) is known to be critical for intracellular growth and virulence for many bacteria, but its role in rickettsiae is unknown. Here, we describe the analysis of lspA, encoding a putative SPase II, an essential component of lipoprotein processing in gram-negative ... More
AuthorsAbrahamsson AE, Geron I, Gotlib J, Dao KH, Barroga CF, Newton IG, Giles FJ, Durocher J, Creusot RS, Karimi M, Jones C, Zehnder JL, Keating A, Negrin RS, Weissman IL, Jamieson CH,
JournalProc Natl Acad Sci U S A
PubMed ID19237556
Recent evidence suggests that a rare population of self-renewing cancer stem cells (CSC) is responsible for cancer progression and therapeutic resistance. Chronic myeloid leukemia (CML) represents an important paradigm for understanding the genetic and epigenetic events involved in CSC production. CML progresses from a chronic phase (CP) in hematopoietic stem ... More