Characterization of tumor-associated Chk2 mutations.
AuthorsWu X, Webster SR, Chen J,
JournalJ Biol Chem
PubMed ID11053450
'The integrity of the DNA damage response pathway is essential for prevention of neoplastic transformation. Several proteins involved in this pathway including p53, BRCA1, and ATM are frequently mutated in human cancer. Checkpoint kinase 2 (Chk2) is a DNA damage-activated protein kinase that lies downstream of ATM in this pathway. ... More
FANCE: the link between Fanconi anaemia complex assembly and activity.
AuthorsPace P, Johnson M, Tan WM, Mosedale G, Sng C, Hoatlin M, de Winter J, Joenje H, Gergely F, Patel KJ,
JournalEMBO J
PubMed ID12093742
'The Fanconi anaemia (FA) nuclear complex (composed of the FA proteins A, C, G and F) is essential for protection against chromosome breakage. It activates the downstream protein FANCD2 by monoubiquitylation; this then forges an association with the BRCA1 protein at sites of DNA damage. Here we show that the ... More