Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy.
Authors Gomes M D; Lecker S H; Jagoe R T; Navon A; Goldberg A L;
JournalProc Natl Acad Sci U S A
PubMed ID11717410
'Muscle wasting is a debilitating consequence of fasting, inactivity, cancer, and other systemic diseases that results primarily from accelerated protein degradation by the ubiquitin-proteasome pathway. To identify key factors in this process, we have used cDNA microarrays to compare normal and atrophying muscles and found a unique gene fragment that ... More
Mediation of the DCC apoptotic signal by DIP13 alpha.
Authors Liu Jiayou; Yao Fayi; Wu Ruping; Morgan Michael; Thorburn Andrew; Finley Russell L Jr; Chen Yong Q;
JournalJ Biol Chem
PubMed ID12011067
DCC (deleted in colorectal cancer) is a candidate tumor suppressor gene. However the function of DCC remains elusive. Previously, we demonstrated that forced expression of DCC induces apoptosis or cell cycle arrest (Chen, Y. Q., Hsieh, J. T., Yao, F., Fang, B., Pong, R. C., Cipriano, S. C. & Krepulat, ... More