Secondary structure of the human cardiac Na+ channel C terminus: evidence for a role of helical structures in modulation of channel inactivation.
Authors Cormier Joseph W; Rivolta Ilaria; Tateyama Michihiro; Yang An-Suei; Kass Robert S;
JournalJ Biol Chem
PubMed ID11741959
'Little is known about the structure of the C terminus of the human cardiac voltage-gated sodium channel alpha subunit (SCN5A), but disease-linked mutations within this 244-amino acid intracellular region of the channel have marked effects on channel inactivation. Here we report a structural analysis of the C-terminal tail of the ... More